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Hormone Replacement Therapy HRT Health Risks - Research Studies
Women's Health Initiative and National Cancer Institute Studies In 1993, the Women's Health Initiative (WHI), a project sponsored by National Institutes of Health (NIH), began a study of approximately 160,000 women aged 50 - 79. Part of the WHI study examined the benefits and risks associated with hormone replacement therapy (HRT), studying approximately 16,600 women. The WHI study looked at two distinct groups of women using hormone replacement therapy: those using estrogen-only therapy and those using combined estrogen plus progestin hormone replacement therapy (HRT). In July 2002, the portion of WHI study involving women who were prescribed combination hormone replacement therapy (HRT) was halted due to the increased risks of breast cancer, heart attack, stroke and blood clots that were observed in the study. The data collected in the WHI study has prompted a re-examination of the appropriateness of hormone replacement therapy. An update to the WHI study that was issued in March 2004 asked WHI participants, without an intact uterus to stop taking their estrogen-only hormone replacement therapy (HRT). In issuing the March 2004 update, the WHI concluded that the risks associated with estrogen-only hormone replacement therapy (HRT) outweighed the benefits that it offered. Specifically, the WHI data demonstrated that for every 10,000 women taking estrogen-only hormone replacement therapy (HRT), 12 more will suffer a stroke than would otherwise be the case if the women were not using estrogen-only hormone replacement therapy (HRT). The March 2004 update to the WHI study, focusing on estrogen-only hormone replacement therapy (HRT), was inconclusive (uncertain) with respect to the association between estrogen-only HRT and blood clots. Also in 2002, the National Cancer Institute published a study that suggested an association between the use of estrogen-only hormone replacement therapy (HRT) and the development of ovarian cancer. The data suggested that the risk of developing ovarian cancer increased with the length of time estrogen-only HRT was used. Findings The data collected by the Women's Health Initiative (WHI) and the National Cancer Institute demonstrated that the use of both combination (estrogen and progestin) hormone replacement therapy (HRT) and estrogen-only hormone replacement therapy (HRT) carried certain health risks. For combination (estrogen and progestin) hormone replacement therapy (HRT), the data indicated the following:
Please click here if you or a loved one used Hormone Replacement Therapy (HRT) medications and suffer from:
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